HLA mismatches and hematopoietic cell transplantation: structural simulations assess the impact of changes in peptide binding specificity on transplant outcome
Identifieur interne : 006130 ( Main/Exploration ); précédent : 006129; suivant : 006131HLA mismatches and hematopoietic cell transplantation: structural simulations assess the impact of changes in peptide binding specificity on transplant outcome
Auteurs : Chen Yanover [États-Unis] ; Effie W. Petersdorf [États-Unis] ; Mari Malkki [États-Unis] ; Ted Gooley [États-Unis] ; Stephen Spellman [États-Unis] ; Andrea Velardi [Italie] ; Peter Bardy [Australie] ; Alejandro Madrigal [Royaume-Uni] ; Jean-Denis Bignon [France] ; Philip Bradley [États-Unis]Source :
- Immunome research [ 1745-7580 ] ; 2011.
Abstract
The success of hematopoietic cell transplantation from an unrelated donor depends in part on the degree of Human Histocompatibility Leukocyte Antigen (HLA) matching between donor and patient. We present a structure-based analysis of HLA mismatching, focusing on individual amino acid mismatches and their effect on peptide binding specificity. Using molecular modeling simulations of HLA-peptide interactions, we find evidence that amino acid mismatches predicted to perturb peptide binding specificity are associated with higher risk of mortality in a large and diverse dataset of patient-donor pairs assembled by the International Histocompatibility Working Group in Hematopoietic Cell Transplantation consortium. This analysis may represent a first step toward sequence-based prediction of relative risk for HLA allele mismatches.
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PubMed: 24482668
PubMed Central: 3904355
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We present a structure-based analysis of HLA mismatching, focusing on individual amino acid mismatches and their effect on peptide binding specificity. Using molecular modeling simulations of HLA-peptide interactions, we find evidence that amino acid mismatches predicted to perturb peptide binding specificity are associated with higher risk of mortality in a large and diverse dataset of patient-donor pairs assembled by the International Histocompatibility Working Group in Hematopoietic Cell Transplantation consortium. This analysis may represent a first step toward sequence-based prediction of relative risk for HLA allele mismatches.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sasazuki, T" uniqKey="Sasazuki T">T Sasazuki</name></author><author><name sortKey="Juji, T" uniqKey="Juji T">T Juji</name></author><author><name sortKey="Morishima, Y" uniqKey="Morishima Y">Y Morishima</name></author><author><name sortKey="Kinukawa, N" uniqKey="Kinukawa N">N Kinukawa</name></author><author><name sortKey="Kashiwabara, H" uniqKey="Kashiwabara H">H Kashiwabara</name></author><author><name sortKey="Inoko, H" uniqKey="Inoko H">H Inoko</name></author><author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T Yoshida</name></author><author><name sortKey="Kimura, A" uniqKey="Kimura A">A Kimura</name></author><author><name sortKey="Akaza, T" uniqKey="Akaza T">T Akaza</name></author><author><name sortKey="Kamikawaji, N" uniqKey="Kamikawaji N">N 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sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author><author><name sortKey="Lund, O" uniqKey="Lund O">O Lund</name></author><author><name sortKey="Buus, S" uniqKey="Buus S">S Buus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crooks, Ge" uniqKey="Crooks G">GE Crooks</name></author><author><name sortKey="Hon, G" uniqKey="Hon G">G Hon</name></author><author><name sortKey="Chandonia, Jm" uniqKey="Chandonia J">JM Chandonia</name></author><author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gray, Jj" uniqKey="Gray J">JJ Gray</name></author><author><name sortKey="Moughon, S" uniqKey="Moughon S">S Moughon</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Schueler Furman, O" uniqKey="Schueler Furman O">O 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Kooperberg</name></author><author><name sortKey="Huang, E" uniqKey="Huang E">E Huang</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Bradley, P" uniqKey="Bradley P">P Bradley</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misura, Kms" uniqKey="Misura K">KMS Misura</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Metropolis, Na" uniqKey="Metropolis N">NA Metropolis</name></author><author><name sortKey="Rosenbluth, Aw" uniqKey="Rosenbluth A">AW Rosenbluth</name></author><author><name sortKey="Rosenbluth, Nm" uniqKey="Rosenbluth N">NM Rosenbluth</name></author><author><name sortKey="Teller, Ah" uniqKey="Teller A">AH Teller</name></author><author><name sortKey="Teller, E" uniqKey="Teller E">E Teller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Td" uniqKey="Schneider T">TD Schneider</name></author><author><name sortKey="Stephens, Rm" uniqKey="Stephens R">RM Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delano, Wl" uniqKey="Delano W">WL Delano</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Yanover, Chen" sort="Yanover, Chen" uniqKey="Yanover C" first="Chen" last="Yanover">Chen Yanover</name></region><name sortKey="Bradley, Philip" sort="Bradley, Philip" uniqKey="Bradley P" first="Philip" last="Bradley">Philip Bradley</name><name sortKey="Gooley, Ted" sort="Gooley, Ted" uniqKey="Gooley T" first="Ted" last="Gooley">Ted Gooley</name><name sortKey="Malkki, Mari" sort="Malkki, Mari" uniqKey="Malkki M" first="Mari" last="Malkki">Mari Malkki</name><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name></country><country name="Italie"><noRegion><name sortKey="Velardi, Andrea" sort="Velardi, Andrea" uniqKey="Velardi A" first="Andrea" last="Velardi">Andrea Velardi</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Bardy, Peter" sort="Bardy, Peter" uniqKey="Bardy P" first="Peter" last="Bardy">Peter Bardy</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Madrigal, Alejandro" sort="Madrigal, Alejandro" uniqKey="Madrigal A" first="Alejandro" last="Madrigal">Alejandro Madrigal</name></noRegion></country><country name="France"><noRegion><name sortKey="Bignon, Jean Denis" sort="Bignon, Jean Denis" uniqKey="Bignon J" first="Jean-Denis" last="Bignon">Jean-Denis Bignon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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